Title

Investigation of the Role of RASSF1A in the Cell Death Response in Cancer Models

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Abstract

This project explored how the RASSF1A-mediated cell death response confers a protective effect against human cancers. RASSF1A, a tumor suppressor protein, functions in inducing apoptosis in abnormal cells. The mechanism by which RASSF1A interacts with TNF-R1; it is this association with TNF-R1 that initiates the apoptotic response. In addition, experimental results suggest that the relationship between RASSF1A and Grb2, an anti-apoptotic protein, may be more complex than that between RASSF1A and other anti-apoptotic proteins. Taken together, these experiments shed light on the role played by RASSF1A in human cancers; in particular, how cell death is chosen over survival in abnormal cells.

Disciplines

Biological and Chemical Physics | Physical Sciences and Mathematics | Physics

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