This paper examines economic trends and spatial location patterns for female high-technology entrepreneurs in four U.S. regions. The results show that women entrepreneurs are more likely to start firms in female-typed high-tech sectors than in male-typed high-tech sectors. Female-typed high-tech firms are smaller and less profitable than their male-typed counterparts. The examination of intra-metropolitan location patterns of women-owned high-tech firms revealed a tilt towards the suburbs. The male-typed high-tech firms tend to cluster in regional high-tech corridors thereby taking advantage of important resources and localization economies. The findings confirm previous studies about the female nature of women’s business ownership.