Corporate entrepreneurship is more relevant than ever, as a viable means for existing organizations to continuously explore and exploit previously unexploited opportunities, thereby moving the organization (or some subset of individuals) to a new state of being. Focusing increasingly on the integration of strategic advantage-seeking and entrepreneurial opportunity-seeking behavior, the perspective Strategic Entrepreneurship (SE) emphasizes the importance of managing entrepreneurial resources strategically in order to obtain competitive advantage through corporate entrepreneurship. Acknowledging and building upon the theoretical contributions of SE, as well as the Schumpeterian perspective on the degree of innovation involved in entrepreneurial activity, the research presented in this paper explores empirical relationships between strategic advantage-seeking and opportunity-seeking behavior leading to radical innovation in a corporate context.