Theoretically, entrepreneurs are their own bosses, enjoy greater (personal) freedom, and have the flexibility to accommodate family responsibilities. In reality, however, entrepreneurs’ freedom is restricted by the responsibility for the venture; its survival and performance (Hornaday & Aboud, 1987; Parasuraman et al., 1996). In contrast, family responsibilities limit entrepreneurs’ ability to devote time and energy to the venture. Even though researchers have acknowledged that conflict between work and family may pose constraints for entrepreneurs (Loscocco et al., 1991; Stoner et al., 1990), the effect of work-and-family conflict as it relates to entrepreneurs’ job stress and job satisfaction has not yet been explored. The present study provides empirical tests of the individual-level relationships between entrepreneurs’ work-and-family conflict, job stress, and job satisfaction.