We adopt a systems perspective to explore university entrepreneurship. By a systems perspective, we mean the exploration of the relationships and interactions among the different components of the university entrepreneurship ecosystem – external environment, university’s institutional environment, technology transfer office (TTO), faculty/researchers, industry licensees and executives of incubated startups – to identify mutually causal processes and pathologies (Perrow, 1984; Masuch, 1985) that influence entrepreneurial outcomes.