Universities are today increasingly acknowledged as powerful drivers of innovation, job creation and economic growth. To promote and support university-based entrepreneurship there has been a tremendous increase in the supply of entrepreneurship courses and the creation of business incubators. As a result of this development there is an increasing group of entrepreneurs that have been educated or fostered in the university context, and who often continue to develop their new ventures in close interaction with the university. The principal research question we ask in this paper is whether university entrepreneurs have a different resource logic compared to entrepreneurs that start up their ventures independently of the university and its surrounding innovation system. Resource logic is in the paper defined as a set of ideas for how to secure and use resources in the start-up process, and we link this concept to three streams of research that can be related to the resource logic of entrepreneurs; effectual decision making, bootstrapping orientation; and personal networking.