“Organizational failure” is often viewed as the result of poor financial performance or the lack of fit between an organization and its environment. Little research, however, has investigated specific non-financial antecedents of firm failure. We propose that job burnout is a primary determinant of venture failure. Job burnout is a psychological syndrome that involves chronic emotional and interpersonal stressors at one’s job and the individual’s subsequent responses to the work, job, coworkers, clients, organization, and themselves. Our aim is to extend theory by proposing a relationship between burnout and venture failure.