Despite the fact that entrepreneurship and health are both rightly entitled “economic engines” (Mirvis & Chang, 2002; Parker, 2005; Schumpeter, 1935), we have scarce insights in how entrepreneurial activities shape individuals’ health or vice versa. The entrepreneur is said to be the foundation and fountainhead for all other resources that form an enterprise (Green et al., 1999). Entrepreneurs tend to be fully immersed in their businesses. In this paper, we assess whether job characteristics, such as business size, autonomy, work load and business networks influence entrepreneurs’ perception of social support and health.