Technology business incubators have been around for about half a century. Despite their increasing popularity, one major question that is often raised is the return one gets on these investments. Although most efforts have brought an interesting array of often descriptive accounts in examining incubators’ performance, some do provide conceptual or integrative frameworks. However, there is a general believe that the jury is still out in terms of the overall effectiveness of these investments. This paper adopts a resource-based view of incubator performance in order to better understand why some incubator programs are more successful than others in supporting the development of new technology or science-based firms (NTSBF), in a unique and largely unexplored setting.