Despite the general finding that a positive association exists between entrepreneurial orientation (EO) and performance of the firm, the evidence is not consistent, and there is wide variation in the magnitude of the reported impact. Researchers make the case that the examination of a simple bivariate link, often with constrained methods, provides an inadequate assessment of this focal relationship (Wang, 2008). Accordingly, scholars have called for wide-ranging modeling of the impact of EO on firm performance (Slevin & Terjesen, 2011). We respond to this call by testing a comprehensive, multi-sequential meditational model, with a multi-theoretic approach.