Several recent studies have evidenced that Indian American immigrant entrepreneurs have been playing an increasingly important role in the economic growth in the United States. Despite the extraordinary success achieved by Indian American immigrant entrepreneurs of Indian origin in the high-tech industries (Hart et al., 2009; Saxenian, 1999, 2006), the key cognitive and behavioral drivers of their success remain largely unexplored. The purpose of this qualitative study was to explore the linkages between the perceptions of risk and opportunity among Indian American immigrant entrepreneurs.