High-growth entrepreneurship emerges as a crucial phenomenon within the entrepreneurship domain. In turn, the founder’s aspirations and expectations have been proved as chief contributors to firm growth. Since every high-impact firm began as a start-up, the study of growth expectations in new ventures is thus relevant to understanding the phenomenon of high-growth entrepreneurship. At the same time, women’s participation in high-growth firms constitutes a recent and necessary research demand. Based on previous evidence we can expect gender to play a role in the establishment of an entrepreneur’s expectation for high growth. Specifically, we seek to evaluate the direct effect of gender on high-growth expectation, as well as whether the impact of variables explaining high-growth expectation varies by gender. We propose a model of explanatory variables at the individual and organizational level, by integrating two theoretical perspectives: social cognitive theory and the resource-based view.