Scholars agree that entrepreneurs’ networks and knowledge are important during early venture formation and recent network research has begun investigating how the interplay between entrepreneurs’ knowledge sets and overall network structure (e.g., overall network size) relate to venture performance. Little research has examined how entrepreneurs’ knowledge and subsets (e.g., family, friends, coworkers, etc.) of network ties relate to performance outcomes. One subset of ties recently studied is family versus non-family ties, although thorough investigation has been neglected. This is problematic because some research suggests benefits accrued from family ties may vary from non-family ties. This paper examines and finds that entrepreneurs’ knowledge and subsets of network ties (non-family ties) systematically relate to the number of employees in young ventures.