In this study, we offer new theoretic rationale to explain how entrepreneurial orientation (EO) contributes to firm growth. We propose that EO exhibits an inverse U-shaped relationship with firm growth, predicated on the argument that a constrained number of new entrepreneurial opportunities imply a finite limit to a firm’s growth prospects. Capitalizing on the global nature of our research design, we introduce a new boundary condition to the EO conversation--the macroeconomic risk in a firm’s home country.