Entrepreneurship research has largely attributed positive entrepreneurial outcomes to positive psychological characteristics using theories and empirical associations grounded in mean tendencies. As such, entrepreneurship represents merely a context for general psychological theory rather than an arena for developing unique psychological theory. We venture outside the realm of the ‘normal’ and instead sample extreme individuals at the tail of the distribution. We explore the efficacy of using theories about abnormalities, examining the potential positive effects in entrepreneurship of otherwise negative psychological deviations. Specifically, we explore the implications of ADHD and autism.