It is proposed that personality factors moderate negative effects of entrepreneurs’ job stress on venture performance. Drawing on a sample of 431 entrepreneurs it was found that higher job stress leads to lower venture performance. However, at higher levels of emotional stability, agreeableness, extraversion, and openness to experience, the negative effect of job stress on venture performance are ameliorated; however, a similar effect was not found for the ameliorating role of conscientiousness. Findings have implication for the role of entrepreneurs’ personality in managing venture performance.