Social ties are essential to new firms (Maurer & Ebers, 2006). Social similarity and task complementarity of actors provide favorable conditions to social tie development in new ventures (Hallen, 2008; Vissa, 2011). Yet, not all tie formation investments pay off, because it takes two to tango. While startups may pursue certain connections, these individuals may not reciprocate their interest, even if favorable conditions occur. However, research on entrepreneurial ties seldom focuses on processes underpinning relational asymmetry or analyzes missed opportunities for connection. The goal of this paper is to analyze the factors leading to tie formation asymmetries in entrepreneurship. Asymmetric ties represent missed opportunities for learning, knowledge exchange, and potential faster growth in new firms.