This study examines the role of compassion in explaining social entrepreneur’s (SE’s) motivations for prosocial action. Using life-story interviews, we identified self-compassion, derived from intimate experiences of suffering, and other-regarding compassion, derived from social awareness and value structures. Self-compassion SEs want to alleviate the suffering of others with similar experiences and provide healing for themselves and others. Other-regarding compassion SEs want to alleviate the suffering of others based on strong commitment and calling. We analyzed discovered and created opportunities and imprinting and reflexive mechanisms and time lags of opportunity recognition (OR). We developed a data-driven process model.