This paper investigates the challenges male and female entrepreneurs face when combining management of their firm with family responsibilities. Further, we examine the strategies they adopt to deal with sometimes conflicting, sometimes mutually supportive, requirements and opportunities in the firm and in the family. The study relies on in-depth interviews with 12 male and female entrepreneurs and family business successors of both genders, all with under-aged children. We identify strategies for work-life balance in the business, in the household and in the business household interface. Gender influences both how the work-life challenges are interpreted and the strategies adopted to manage them.